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Mahabharat

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वयाधेर अनिष्ट संस्पर्शाच छरमाद इष्टविवर्जनात दुःखं चतुर्भिर शारीरं कारणैः संप्रवर्तते ॥ ३-२-२१ ॥

'Bodily suffering arises from four main causes: disease, contact with painful things, toil, and lack of desired objects.' ॥ 3-2-21 ॥

english translation