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Astanga Hrudaya

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सर्वायतनसंस्थानसन्निपाते तदात्मकम् । उन्मादं दारुणं विद्यात्तं भिषक् परिवर्जयेत् ॥ १४ ॥

In that caused by all the Doshas (increasing together) the symptoms of all the Doshas appear simultaneously. This insanity is difficult to cure, hence the physician should reject it.

english translation

Chapter 6

Verse 15