Kalpa-sthana, the fifth division of the ancient Sushruta Samhita, is the classical Ayurvedic treatise’s pharmacopeia. Composed in the first millennium BCE–early centuries CE, it records meticulous methods for preparing medicines—decoctions, powders, oils, ghritas and electuaries—alongside purification, preservation and standards of dosage. A distinct strain of its chapters treats poisons and antidotes, emergency care for snakebites and systematic detoxification. Key themes are formulation technique, quality control of raw drugs, therapeutic intent and safety. Today Kalpa-sthana remains relevant as a foundation for traditional pharmaceutics and toxicology, informing herbal medicine production, integrative therapeutics and efforts to standardize and safely apply millennia-old remedies in modern healthcare.