The Preamble to Kalpa-sthana (the 7th Sthana of the Charaka Saṃhita) opens the classical Ayurvedic manual with practical wisdom on drug-making, therapeutic formulations and safety. Rooted in the ancient Agniveśa–Charaka tradition and later redactions, it sets out principles for preparation, purification, compatibility, potency, dosing, storage and testing of medicines — including management of poisons. Key themes are pharmacology grounded in observation, quality control, individualised dosing, ethical manufacture and prevention of harm. Today its insistence on careful processing, standardized procedures and patient-centered therapy resonates with modern pharmaceutics, toxicology and integrative medicine, offering a time-honored framework for safe, effective herbal therapeutics and responsible practice.