The effects of poison increase due to hunger, thirst, exposure to sun/heat, debility, anger, grief, fear, physical exertion, indigestion, watery stools, and aggravation of Pitta and Vata;
as well as by smelling the flowers and fruits of sesame (tila – Sesamum indicum), exposure to earth vapors, thunder of rain clouds, hearing the trumpeting of elephants, squeaking of mice, sound of musical instruments, during critical periods of poisoning (visha sankata),
direct/easterly wind, fragrance of blue water lily (utpala – Nymphaea stellata), and sexual arousal or desire. During the rainy season (Varsha), because of its aquatic origin, poison becomes excessively moist and liquefied like jaggery and spreads everywhere;
but at the end of the rainy season, the star Agastya (Canopus) destroys its intensity. Therefore, with the departure of the rain clouds (in autumn / Sharat), the poison attains mild potency.
The wise physician should determine the appropriate treatment only after considering the nature, customization, season, location, stage, strength and weakness (of the poison and the patient).