Astanga Hrudaya
तथा स्वधातुवैषम्यनिमित्तमपि सर्वदा। विकारजातं त्रीन्दोषाण् तेषां कोपे तु कारणम्॥३४॥
Dosha get vitiated, then cause vitiation of body tissues (Dhatu) and waste products (Mala) to cause disease. Three kinds of causes for Dosha increase -
english translation