When the edible becomes poisonous by particular processing such as in case of peacock's meat attached to castor stick (eranda), it is known to be antagonistic in terms of processing.
मृदकोष्ठस्य गुरु च भेदनीयं तथा बहु| एतत् कोष्ठविरुद्धं तु, विरुद्धं स्यादवस्थया ||९५||
Antagonism in bowels is that when too little drug of mild potency with limited effectiveness in breaking hard mass is administered to persons suffering from hard bowels, and on the other hand, heavy, highly potent drug is administered to those suffering from soft bowel.