Charak Samhita

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मृदकोष्ठस्य गुरु च भेदनीयं तथा बहु| एतत् कोष्ठविरुद्धं तु, विरुद्धं स्यादवस्थया ||९५||

sanskrit

Antagonism in bowels is that when too little drug of mild potency with limited effectiveness in breaking hard mass is administered to persons suffering from hard bowels, and on the other hand, heavy, highly potent drug is administered to those suffering from soft bowel.

english translation

mRdakoSThasya guru ca bhedanIyaM tathA bahu| etat koSThaviruddhaM tu, viruddhaM syAdavasthayA ||95||

hk transliteration