[Types of viruddha (incompatibility)] That, which is antagonistic with respect to place, time, agni, dose, suitability, dosha, processing, potency, bowels, health condition, order, contra-indication, indication,
If in an arid zone rough and sharp substances, and in marshy region unctuous and cold ones are used, those would be known to be antagonistic in terms of place.
कालतोऽपि विरुद्धं यच्छीतरूक्षादिसेवनम्| शीते काले, तथोष्णे च कटुकोष्णादिसेवनम् ||८९||
Likewise, if one takes rough and cold food in the winter and pungent and hot articles in the summer, it is antagonistic in terms of time. Similar is the antagonism of food and drinks in four types of agni.