Charak Samhita

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तत्र यदसाध्यं तदसाध्यतां नातिवर्तते, साध्यं पुनः किञ्चित् साध्यतामतिवर्तते कदाचिदपचारात्| साध्यानि हि षट् काकणकवर्ज्यान्यचिकित्स्यमानान्यपचारतो वा दोषैरभिष्यन्दमानान्यसाध्यतामुपयान्ति ||९||

sanskrit

[Prognosis] The incurable disease never give up its incurability (never become curable). The curable disease may sometimes become incurable due to misconduct (not following the diet and lifestyle regulations properly). The six (types of) kushtha are curable except kakanaka. However if not treated properly, they may become incurable due to lack of timely management, improper management and constantly excess aggravation of doshas.

english translation

tatra yadasAdhyaM tadasAdhyatAM nAtivartate, sAdhyaM punaH kiJcit sAdhyatAmativartate kadAcidapacArAt| sAdhyAni hi SaT kAkaNakavarjyAnyacikitsyamAnAnyapacArato vA doSairabhiSyandamAnAnyasAdhyatAmupayAnti ||9||

hk transliteration