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Charak Samhita

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ज्वरातिसारौ शोफान्ते श्वयथुर्वा तयोः क्षये। दुर्बलस्य विशेषेण नरस्यान्ताय जायते ॥१८॥

A person whose all the three doshas are vitiated, emaciated, having no strength, is untreatable.

english translation