Charak Samhita

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शीघ्रं व्यवायिभावादाशु व्याप्नोति केवलं देहम् | तीक्ष्णत्वान्मर्मघ्नं प्राणघ्नं तद्विकासित्वात् ||२६||

due to rapidly acting, it quickly permeates through the nutrient fluid; vyavayi guna spreads it throughout the body instantaneously. Tikshna guna (sharply acting) property causes injury to marmas, vikashi guna results in death of the patient. Due to laghu guna it becomes difficult to manage therapeutically;

english translation

zIghraM vyavAyibhAvAdAzu vyApnoti kevalaM deham | tIkSNatvAnmarmaghnaM prANaghnaM tadvikAsitvAt ||26||

hk transliteration by Sanscript