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Charak Samhita

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दुरुपक्रमं लघुत्वाद्वैशद्यात् स्यादसक्तगतिदोषम् । दोषस्थानप्रकृतीः प्राप्यान्यतमं ह्युदीरयति ॥२७॥

because of vaishadya guna, it pervades all over the body with dosha without any obstruction in circulation. Depending upon the location of dosha and prakriti of patient, visha produces several other complications.

english translation