Charak Samhita
चिन्ताकामभयक्रोधशोकोद्वेगादिभिस्तथा। मनस्यभिहते नॄणामपस्मारः प्रवर्तते ॥५॥
The heart (site of consciousness) is obscured by aggravated doshas; and Mind is distressed or annihilated by (affliction of negative emotions like) worry, passion, fright, anger, grief, anxiety etc.
english translation
cintAkAmabhayakrodhazokodvegAdibhistathA। manasyabhihate nRRNAmapasmAraH pravartate ॥5॥
hk transliteration by Sanscript