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Charak Samhita

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धमनीभिः श्रिता दोषा हृदयं पीडयन्ति हि। सम्पीड्यमानो व्यथते मूढो भ्रान्तेन चेतसा ॥६॥

[Pathogenesis and features of pre-ictal phase] (By the above mentioned factors) doshas located in the vessels (or dhamani, channels that carry nutrients) afflict the heart. Thus person suffers due to bewildered mind.

english translation