Astanga Hrudaya
प्रभूते शोधनं, तद्धि मूलादुन्मूलयेन्मलान्। एवमन्यानपि व्याधीन् स्वनिदानविपर्ययात्॥२२॥
If it is severe, then Shodhana (purification Panchakarma therapy) is necessary; for these will expel out the Dosha and Ama from the very root.
english translation
prabhUte zodhanaM, taddhi mUlAdunmUlayenmalAn। evamanyAnapi vyAdhIn svanidAnaviparyayAt॥22॥
hk transliteration by Sanscript