Astanga Hrudaya

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हरेद्बहूंश्चलान् दोषानल्पानल्पान् पुनःपुनः। दुर्बलस्य मृदुद्रव्यैरल्पान् संशमयेत्तु तान्॥५१॥

Large dose given once creates doubt of death; The drug in small and repeated doses will eliminate the circulating Doshas little by little; in a weak person, little quantity of Doshas should only be mitigated by mild drugs, they need not be expelled out by purification therapies .

english translation

haredbahUMzcalAn doSAnalpAnalpAn punaHpunaH। durbalasya mRdudravyairalpAn saMzamayettu tAn॥51॥

hk transliteration by Sanscript