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Charak Samhita

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एवंवादिनं भगवन्तमात्रेयमग्निवेश उवाच- नैतानि भगवन्! पञ्च कषायशतानि पूर्यन्ते, तानि तानि ह्येवाङ्गान्युपप्लवन्ते तेषु तेषु महाकषायेष्विति ॥२१॥

While Lord Atreya was saying thus, Agnivesha, inquired, “Sir, the number five hundred does not match with regards to medicines (or medicinal herbs) because the same constituents are repeated in these classes of medicines.”

english translation