Charak Samhita

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नेन्द्रियाणि न चैवार्थाः सुखदुःखस्य हेतवः। हेतुस्तु सुखदुःखस्य योगो दृष्टश्चतुर्विधः ॥१३०॥

Neither the sense organs nor their objects alone can bring about happiness or miseries. The latter are in fact caused by the fourfold contacts mentioned above (viz., proper utilization, wrong utilization, excessive utilization and non-utilization).

english translation