Charak Samhita

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सन्तीन्द्रियाणि सन्त्यर्था योगो न [१] च न चास्ति रुक्। न सुखं, कारणं तस्माद्योग एव चतुर्वधः ॥१३१॥

Even if there are sense organs and their objects present, there would be no disease, nor any happiness unless the fourfold combination is involved. So, this contact itself constitutes a causative factor for happiness and miseries.

english translation