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Charak Samhita

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ते तु खलु निजागन्तुविशेषेण साध्यासाध्यविशेषेण च प्रविभज्यमानाः पञ्च सन्तो द्वावेव भवतः। तौ च परस्परमनुबध्नीतः कदाचिद्यथोक्तहेतुसंसर्गात् । तयोः संसृष्टमेव पूर्वरूपं भवति, संसृष्टमेव च लिङ्गम्। तत्रासाध्यसंयोगं साध्यासाध्यसंयोगं चासाध्यं विद्यात्, साध्यं तु साध्यसंयोगम् । तस्य साधनं साधनसंयोगमेव विद्यादिति ॥१८॥

The unmada of five types can be further classified as endogenous or exogenous or as curable or incurable. At times, due to the combination of etiological factors (of endogenous and exogenous types), these could also manifest in hybrid forms. Such forms would exhibit a combination of both the types of unmada in their premonitory as well as actual symptoms. However, it is important to note that: 1. Combination of the incurable types or of the curable and incurable types result in an incurable condition. 2. Combination of curable types results in curable conditions that should be treated using a combination of therapies.

english translation