इष्टवर्णरसस्पर्शगन्धार्थं प्रति चामयम्| अतो विरुद्धवीर्याणां प्रयोग इति निश्चितम्||४६||
The rationality for using viruddha virya (opposite quality drugs or antagonistic) drugs along with main drug are to impart pleasant color, good taste, agreeable smell and touch and relation to the specific disorders.
The quality and action of drugs can be enhanced by the proper triturating with either swarasa (juice) or kwatha (decoction) of the same drug or of the other drugs with similar qualities and action.
This method also potentiates the multidimensional action of the preparation. By the combination and separation of drugs, kala (time), sanskara (processings), & yukti (proper planning) one can modify the potency of medicaments.
There by minute dose can produce greater benefits and vice versa. Six hundred formūlation mentioned in Kalpa Sthana are practically experienced combination for the use.
स्वबुद्ध्यैवं सहस्राणि कोटीर्वाऽपि प्रकल्पयेत्| बहुद्रव्यविकल्पत्वाद्योगसङ्ख्या न विद्यते||५०||
Such thousands or crores of combination can be planned & prepared by the wise physician with his own intellect and experience. There is no limit for framing new formulations as there exists a wide scope for multidrug combinations.