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Charak Samhita

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स्वरस्य दुर्बलीभावं हानिं च बलवर्णयोः। रोगवृद्धिमयुक्त्या च दृष्ट्वा मरणमादिशेत् ॥१२॥

[Poor prognosis with feeble voice] If a patient develops weakness of voice, diminution of strength and complexion, and aggravation of disease without an apparent cause then such patient will die soon.

english translation