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Charak Samhita

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अतिप्रवृद्ध्या रोगाणां मनसश्च बलक्षयात्। वासमुत्सृजति क्षिप्रं शरीरी देहसञ्ज्ञकम् ॥२३॥

[Near death signs] In case of extreme advancement of the disease and weaker psychological strength, the soul immediately leaves the body.

english translation