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Charak Samhita

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ग्रीवावमर्दो बलवाञ्जिह्वाश्वयथुरेव च। ब्रध्नास्यगलपाकश्च यस्य पक्वं तमादिशेत् ॥१५॥

A person having acute and severe squeezing type of pain in neck, swelling of tongue along with inflammation of scrotum, throat and mouth should be considered as ripen (for death).

english translation