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Charak Samhita

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तथा पिप्लुव्यङ्गतिलकालकपिडकानामन्यतमस्यानने जन्मातुरस्यैवमेवाप्रशस्तं विद्यात् ॥११॥

Similarly, sudden appearance of piplu (Acne), vyanga (Pigmented skin), tilakalaka (Mole) and pidaka (Boil) on the face of the patient is inauspicious.

english translation