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Charak Samhita

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गतिरूर्ध्वमधश्चैव रक्तपित्तस्य दर्शिता। ऊर्ध्वा सप्तविधद्वारा द्विद्वारा त्वधरा गतिः ॥१५॥

[Gati (direction of flow) and prognosis] Movement of raktapitta is directed upwards and downwards, the former through seven orifices and the latter through two orifices. There are seven orifices in head and two below.

english translation