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Charak Samhita

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रोगराट् सर्वभूतानामन्तकृद्दारुणो ज्वरः। तस्माद्विशेषतस्तस्य यतेत प्रशमे भिषक् ॥३४५॥

Jwara is the king of diseases and it causes the death of all creatures and is of serious nature. Therefore, the physician should make special efforts for its treatment.

english translation