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Charak Samhita

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सोऽल्परक्तोऽल्पमेदस्को निःसारः शिथिलेन्द्रियः। वैवर्ण्यं भजते, तस्य हेतुं शृणु सलक्षणम्॥६॥

and the fatty tissue (meda dhatu) and absence of the vitality of all the tissues (nihsara) decreases functional status of sense organs (sithilendriyah) and discoloration of the body. Hetu (etiological factors and pathogenesis) and the sign and symptoms of the disease will be explained hereafter

english translation