Charak Samhita

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न तु केवलं गुणप्रभावादेव द्रव्याणि कार्मुकाणि भवन्ति; द्रव्याणि हि द्रव्यप्रभावाद्गुणप्रभावाद्द्रव्यगुणप्रभावाच्च तस्मिंस्तस्मिन् काले तत्तदधिकरणमासाद्य तां तां च युक्तिमर्थं च तं तमभिप्रेत्य यत् कुर्वन्ति, तत् कर्म; येन कुर्विन्ति, तद्वीर्यं; यत्र कुर्वन्ति, तदधिकरणं; यदा कुर्वन्ति, स कालः; यथा कुर्वन्ति, स उपायः; यत् साधयन्ति, तत् फलम् ||१३||

sanskrit

[Description of drug action] The activity of drugs is not due to its properties only, but their own intrinsic composition, properties and both combined together in particular time, on reaching a particular locus, with a particular mechanism and objective are also involved in the mode of action of drug. What they perform is karma (action), by means of which they act is veerya (potency), where they act is adhikarana (locus of action), when they act is kala (time), how they act is upaya (mechanism) and what they achieve is phalam (result).

english translation

na tu kevalaM guNaprabhAvAdeva dravyANi kArmukANi bhavanti; dravyANi hi dravyaprabhAvAdguNaprabhAvAddravyaguNaprabhAvAcca tasmiMstasmin kAle tattadadhikaraNamAsAdya tAM tAM ca yuktimarthaM ca taM tamabhipretya yat kurvanti, tat karma; yena kurvinti, tadvIryaM; yatra kurvanti, tadadhikaraNaM; yadA kurvanti, sa kAlaH; yathA kurvanti, sa upAyaH; yat sAdhayanti, tat phalam ||13||

hk transliteration