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Charak Samhita

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बलदोषप्रमाणाद्वा विशुद्ध्या रुधिरस्य वा। रुधिरं स्रावयेज्जन्तोराशयं प्रसमीक्ष्य वा ॥१९॥

[Extent of bloodletting] Bloodletting should be done considering the strength of the person, dosha, location of the disease, and until pure blood starts to flow out.

english translation