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Charak Samhita

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द्वयोस्तु खल्वागन्तुनिजयोः प्रेरणमसात्म्येन्द्रियार्थसंयोगः, प्रज्ञापराधः, परिणामश्चेति ॥५॥

[Three major causes of diseases] Unwholesome contact between sense organs and their objects, intellectual defects and effects of time constitute the common causative factors for both the exogenous and endogenous types of diseases.

english translation