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Charak Samhita

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तन्द्रा [२] सोत्क्लेश आनाहो ज्वरः स्तम्भो विसञ्ज्ञता। कुष्ठानि कण्डूः पाण्डुत्वं शोफार्शांस्यरुचिस्तृषा ॥७५॥

Consuming ghrita in such cases could change the physical complexion of the person to that of pitta, lead to loss of consciousness or even death.

english translation