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Charak Samhita

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न सर्पिः केवलं पित्ते पेयं सामे विशेषतः। सर्वं ह्यनुरजेद्देहं [१] हत्वा सञ्ज्ञां च मारयेत् ॥७४॥

Ghrita should not be taken when only pitta is increased and especially when there is ama in the body.

english translation