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Charak Samhita

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ये तु वृद्धाश्च बालाश्च सुकुमाराः सुखोचिताः। रिक्तकोष्ठत्वमहितं येषां मन्दाग्नयश्च ये ॥३८॥

[Persons suitable for lowest dose and its benefits] Those who are old, young (children), those with tender physique, living luxurious life, those who cannot tolerate hunger or have difficulty with empty stomach, those suffering from poor digestion,

english translation