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Charak Samhita

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वमनं न तु दुश्छर्दं दुष्कोष्ठं न विरेचनम्। पाययेतौषधं भूयो हन्यात् पीतं पुनर्हि तौ॥३७॥

Never give emetic drug to people who are unsuitable for vamana; virechana to those with unsuitable koshtha, if medicine intake happens in such conditions it may even lead to death.

english translation