Charak Samhita

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एवमेव पुरुषस्य यदा बीजे बीजभागः प्रदोषमापद्यते, तदा वन्ध्यं जनयति; यदा पुनरस्य बीजे बीजभागावयवःप्रदोषमापद्यते, तदा पूतिप्रजं जनयति; यदा त्वस्य बीजे बीजभागावयवः पुरुषकराणां च शरीरबीजभागानामेकदेशःप्रदोषमापद्यते, तदा पुरुषाकृतिभूयिष्ठमपुरुषं तृणपुत्रिकं नाम जनयति; तां पुरुषव्यापदमाचक्षते ||३१||

sanskrit

In the same way, when the part of the beeja (gene of a sperm) is markedly vitiated, then this gives birth to a vandhya (sterile) child. When the beejabhagavayava (chromosome) is extremely vitiated, then this gives birth to a putipraja (whose child dies before delivery). When the beejabhagavayava of sperm and also portions of the beejabhaga, which are responsible for the production of organs that differentiate a male, are greatly vitiated, then this gives birth to a child who is not a male but only having masculine distinctiveness in abundance. Such a type of child is known as trinaputrika. These deformities are caused by the vitiation of the sperm (male genes and chromosomes).

english translation

evameva puruSasya yadA bIje bIjabhAgaH pradoSamApadyate, tadA vandhyaM janayati; yadA punarasya bIje bIjabhAgAvayavaHpradoSamApadyate, tadA pUtiprajaM janayati; yadA tvasya bIje bIjabhAgAvayavaH puruSakarANAM ca zarIrabIjabhAgAnAmekadezaHpradoSamApadyate, tadA puruSAkRtibhUyiSThamapuruSaM tRNaputrikaM nAma janayati; tAM puruSavyApadamAcakSate ||31||

hk transliteration