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Charak Samhita

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अन्तरेण गुदं गच्छन् नाभिं च सहसाऽनिलः। कृशस्य वङ्क्षणौ गृह्णन् सद्यो मुष्णाति जीवितम् ॥८॥

If a weak patient develops suffering in the groin region due to sudden aggravation of vata between the anus and the umbilicus, then he instantly dies.

english translation