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Charak Samhita

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तस्मिन् काले पचत्यग्निर्यदन्नं कोष्ठसंश्रितम्। मलीभवति तत् प्रायः कल्पते किञ्चिदोजसे ॥४१॥

Once, however, there is any obstruction to srotas or if there is diminution of stable tissue elements like rakta or if there is diminution of dhatu-ushmas or dhatvagnis then rajayakshma is manifested.

english translation