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Charak Samhita

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अयथाबलमारम्भं वेगसन्धारणं क्षयम्। यक्ष्मणः कारणं विद्याच्चतुर्थं विषमाशनम् ॥१३॥

[Four important c ausative factors of disease] Over–exertion beyond one’s capacity, suppression of natural urges, depletion of tissue elements and irregular dietary habits are the etiological factors of rajayakshma.

english translation