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Charak Samhita

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पाषाणकठिनपरुषे सुप्ते कुष्ठे स्थिरे पुराणे च। पीतागदस्य कार्यो विषैः प्रदेहोऽगदैश्चानु ॥५५॥

If kushtha is hard like stone with numbness, it is stable (not spreading) and chronic in such cases antidotes should be given internally prior to the application of poison in the form of lepa followed by application of antidote.

english translation