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Charak Samhita

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येषु न शस्त्रं क्रमते स्पर्शेन्द्रियनाशनानि यानि स्युः। तेषु निपात्यः क्षारो रक्तं दोषं च विस्राव्य ॥५४॥

When there is loss of sensation and/or surgical interventions is prohibited, kshara should be used after rakta and dosha are eliminated.

english translation