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Charak Samhita

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इत्येवं षड्विधं कालमनवेक्ष्य भिषग्जितम् । प्रयुक्तमहिताय स्यात् सस्यस्याकालवर्षवत् ॥३०७॥

The vaidya who does not follow the above six dosage timings of administration of medicines would not treat the disease properly and as unseasonal rain damages the crops; same way the medicines given at the wrong time damages health of patient.

english translation