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देशकालप्रमाणानां सात्म्यासात्म्यस्य चैव हि | सम्यग्योगोऽन्यथा ह्येषां पथ्यमप्यन्यथा भवेत् ||२९३||

The medicines shall be prescribed after due consideration of desha (habitat), kala (season), pramana (dosage), satmya(adaptability) and asatmya (non-adaptability). If this is properly considered, then it is pathya (beneficial to body systems). Otherwise it is non-beneficial.

english translation

dezakAlapramANAnAM sAtmyAsAtmyasya caiva hi | samyagyogo'nyathA hyeSAM pathyamapyanyathA bhavet ||293||

hk transliteration by Sanscript