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Charak Samhita

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परिक्षयादायुषश्चाप्यनाहाराच्छ्रमात् क्लमात् । जरासम्भवजं क्लैब्यमित्येतैर्हेतुभिर्नृणाम् ॥१७९॥

reducing life span, malnutrition, physical exertion & mental exhaustion leads to senility related impotency.

english translation

Chapter 30

Verse 180