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Charak Samhita

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विरेकवमने चोभे सास्थिभेदं प्रकूजनम्। विक्षेपणं च गात्राणां श्वासश्चास्थिगते ज्वरे ॥८०॥

5. Vitiated dosha located in the asthi dhatu cause the following clinical features – diarrhea, emesis, pain in the bones, production of kujana (a sort of cooing sound) convulsive movements of the body and limbs.

english translation