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Charak Samhita

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करोति दुःखं तेष्वेव तस्मात् प्रायेण सन्धिषु । भवन्ति वेदनास्तास्ता अत्यर्थं दुःसहा नृणाम् ॥१५॥

produce different types of vedana (unpleasant sensation like pain etc.) so that there are dukha (pain and other abnormal sensation) in the joints. The vedana (pain) is so severe, which is difficult to tolerate.

english translation