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Charak Samhita

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एते स्थानस्य गाम्भीर्याद्यत्नात् सिध्यन्ति वा न वा । नवान् बलवतस्त्वेतान् साधयेन्निरुपद्रवान् ॥७४॥

all these on account of their seriousness of the seat affected , may or may not be cured even after deliberate treatment. These can be cured when they are of recent origin in strong patient and without any complications.

english translation