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Charak Samhita

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प्राणेश्वरः प्राणभृतां करोति क्रिया च तेषामखिला निरुक्ता । तां देशसात्म्यर्तुबलान्यवेक्ष्य प्रयोजयेच्छास्त्रमतानुसारी ॥२४९॥

both in its own habitat and in other places, both in conditions of occlusion and in no occlusion, and the treatment of all those disease have been fully expounded here. The physician guided by the directions of the science, should administer the treatment, giving full consideration to factors of place, similarity, season and strength.

english translation