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Charak Samhita

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कर्मौजोबलवर्णानां नाशो मृत्युरथापि वा । उदानेनावृते प्राणे तं शनैः शीतवारिणा ॥२०८॥

In condition of occlusion of prana by udana, there will be loss of function, vital essence, strength and complexion or it may even lead to death.

english translation